C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and mediates synapse pruning

Brott, BK , Raissi, AJ , Micheva, KD , Vielmetter, J , Mendes, MS , Baccus, CJ , Huang, J , Shatz, CJ

Proceedings of the National Academy of Sciences of the United States of America 122(38) e2519253122

Synapse pruning sculpts neural circuits throughout life. The human Leukocyte immunoglobulin-like receptor type B2 (LilrB2)/murine Paired immunoglobulin receptor B (PirB) receptors expressed in neurons …

Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology

Karaahmet, Berke , Le, Linh , Mendes, Monique S , Majewska, Ania K , O'Banion, M Kerry

Journal of Neuroinflammation 19(1) 173

Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure

Lowery, Rebecca L , Cealie, MaKenna Y , Lamantia, Cassandra E , Mendes, Monique S , Drew, Paul D , Majewska, Ania K

Journal of Neuroscience Research 99(8) 2008-2025

Fetal alcohol spectrum disorders (FASD) are the most common cause of nonheritable, preventable mental disability and are characterized by cognitive, behavioral, and physical impairments. FASD occurs …

The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo

Mendes, Monique S , Le, Linh , Atlas, Jason , Brehm, Zachary , Ladron-de-Guevara, Antonio , Matei, Evelyn , Lamantia, Cassandra , McCall, Matthew N , Majewska, Ania K

eLife 10

An overview of microglia ontogeny and maturation in the homeostatic and pathological brain

Mendes, Monique S , Majewska, Ania K

The European Journal of Neuroscience 53(11) 3525-3547

Microglia are the resident immune cells of the central nervous system (CNS) and are increasingly recognized as critical players in development, brain homeostasis, and disease pathogenesis. The …

Loss of P2Y12 Has Behavioral Effects in the Adult Mouse

Lowery, Rebecca L , Mendes, Monique S , Sanders, Brandon T , Murphy, Allison J , Whitelaw, Brendan S , Lamantia, Cassandra E , Majewska, Ania K

International Journal of Molecular Sciences 22(4) 1868

While microglia have been established as critical mediators of synaptic plasticity, the molecular signals underlying this process are still being uncovered. Increasing evidence suggests that microglia …

In vivo imaging of the kinetics of microglial self-renewal and maturation in the adult visual cortex

Mendes, Monique S , Le, Linh , Atlas, Jason , Brehm, Zachary , Ladron-de-Guevara, Antonio , Matei, Evelyn , Lamantia, Cassandra , McCall, Matthew N , Majewska, Ania K

bioRxiv

Microglia are the resident immune cells in the brain with the capacity to autonomously self-renew. Under basal conditions, microglial self-renewal appears to be slow and stochastic, although microglia …

Cerebellar microglia are dynamically unique and survey Purkinje neurons in vivo

Stowell, Rianne D , Wong, Elissa L , Batchelor, Hanna N , Mendes, Monique S , Lamantia, Cassandra E , Whitelaw, Brendan S , Majewska, Ania K

Developmental Neurobiology 78(6) 627-644

A Pilot Study of Inhaled CO Therapy in Neonatal Hypoxia-Ischemia: Carboxyhemoglobin Concentrations and Brain Volumes

Douglas-Escobar, Martha , Mendes, Monique , Rossignol, Candace , Bliznyuk, Nikolay , Faraji, Ariana , Ahmad, Abdullah S , Doré, Sylvain , Weiss, Michael D

Frontiers in Pediatrics 6 120

Objective: The objective of this pilot study was to start evaluating the efficacy and the safety (i.e., carboxyhemoglobin concentration of carbon monoxide (CO)) as a putative neuroprotective therapy …

Efficacy of Laropiprant in Minimizing Brain Injury Following Experimental Intracerebral Hemorrhage

Ahmad, Abdullah Shafique , Mendes, Monique , Hernandez, Damian , Doré, Sylvain

Scientific Reports 7(1) 9489

Efficacy of prophylactic flavan-3-ol in permanent focal ischemia in 12-mo-old mice

Leonardo, Christopher C , Mendes, Monique , Ahmad, Abdullah S , Doré, Sylvain

American Journal of Physiology-Heart and Circulatory Physiology 308(6) H583–H591